Archival ReportFunctional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder
Section snippets
Search Strategy
Cortese et al. (6) included 16 studies in adults, published up to June 30, 2011. We updated this meta-analysis (last search on March 15, 2015) using the same search strategy, as detailed in the Supplement.
Study Eligibility Criteria
Studies were retained if 1) they presented data on adults with ADHD; 2) ADHD diagnosis was made according to DSM (III, IV, IV-TR) or ICD (9 or 10); 3) a matched group of healthy subjects was included; 4) data were reported as three-dimensional coordinates in stereotactic space; and 5)
Literature Search
We found 10 pertinent studies (13, 35, 36, 37, 38, 39, 40, 41, 42, 43) published after the search date of our prior meta-analysis (6), increasing the sample size by 40% relative to our previous meta-analysis in adults. Figure 1 shows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) flow chart (44) of the selected studies. Including the 16 previously included datasets (10, 11, 12, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57) from Cortese et al. (6), we
Discussion
This updated meta-analysis of task-based fMRI studies in adults with ADHD is the first to apply meta-analytic connectivity modeling and functional decoding to characterize ADHD-related dysfunctional regions, pointing to possible novel functions of dysfunctional brain regions not necessarily tested in individual studies. These methods leverage a large curated cognitive neuroscience database (BrainMap) to support data-driven interpretation of novel results. This is also the largest ALE
Acknowledgments and Disclosures
This work was supported by Grant Nos. R01MH083246 and R01MH074457, the Helmholtz Portfolio Theme “Supercomputing and Modeling for the Human Brain” and the European Union Seventh Framework Programme (FP7/2007-2013) under Grant No. 604102.
SC has received royalties from Argon Healthcare, Italy (2012–2014). GM was on the advisory boards for Eli Lilly, Shire, and Angelini; has received research grants from Eli Lilly and Shire; and has been a speaker for Eli Lilly, Shire, Lundbeck, and Otsuka. All
References (84)
- et al.
Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD)
Neurosci Biobehav Rev
(2012) - et al.
Differences in feedback- and inhibition-related neural activity in adult ADHD
Brain Cogn
(2009) - et al.
Neural correlates of inhibitory control in adult attention deficit/hyperactivity disorder: Evidence from the Milwaukee longitudinal sample
Psychiatry Res
(2011) Inferring mental states from neuroimaging data: From reverse inference to large-scale decoding
Neuron
(2011)- et al.
Investigating function and connectivity of morphometric findings - Exemplified on cerebellar atrophy in spinocerebellar ataxia 17 (SCA17)
Neuroimage
(2012) - et al.
Behavior, sensitivity, and power of activation likelihood estimation characterized by massive empirical simulation
Neuroimage
(2016) - et al.
Activation likelihood estimation meta-analysis revisited
Neuroimage
(2012) - et al.
Subspecialization in the human posterior medial cortex
Neuroimage
(2015) - et al.
Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHD
Psychiatry Res
(2012) - et al.
Orbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder
Neuroimage
(2012)
The neural basis of sustained and transient attentional control in young adults with ADHD
Neuropsychologia
Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood Attention-Deficit Hyperactivity Disorder (ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switching
J Psychiatr Res
Fronto-striatal underactivation during interference inhibition and attention allocation in grown up children with attention deficit/hyperactivity disorder and persistent symptoms
Psychiatry Res
A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention
Cortex
Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder
Neuroimage
Functional neuroanatomy of working memory in adults with attention-deficit/hyperactivity disorder
Biol Psychiatry
Neural substrates of impaired sensorimotor timing in adult attention-deficit/hyperactivity disorder
Biol Psychiatry
Timing deficits in attention-deficit/hyperactivity disorder (ADHD): Evidence from neurocognitive and neuroimaging studies
Neuropsychologia
The image of time: A voxel-wise meta-analysis
Neuroimage
Entrainment of neural oscillations as a modifiable substrate of attention
Trends Cogn Sci
Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder
Lancet
Semantic conflicts are resolved differently by adults with and without ADHD
Res Dev Disabil
Cortical gray matter in attention-deficit/hyperactivity disorder: A structural magnetic resonance imaging study
J Am Acad Child Adolesc Psychiatry
"Cool" inferior frontostriatal dysfunction in attention-deficit/hyperactivity disorder versus "hot" ventromedial orbitofrontal-limbic dysfunction in conduct disorder: A review
Biol Psychiatry
Differential therapeutic effects of 12-week treatment of atomoxetine and methylphenidate on drug-naive children with attention deficit/hyperactivity disorder: A counting Stroop functional MRI study
Eur Neuropsychopharmacol
Dysfunctional attentional networks in children with attention deficit/hyperactivity disorder: Evidence from an event-related functional magnetic resonance imaging study
Biol Psychiatry
Osmotic release oral system-methylphenidate improves neural activity during low reward processing in children and adolescents with attention-deficit/hyperactivity disorder
Neuroimage Clin
Epidemiology of attention-deficit/hyperactivity disorder across the lifespan
Curr Opin Psychiatry
The worldwide prevalence of ADHD: A systematic review and metaregression analysis
Am J Psychiatry
The age-dependent decline of attention deficit hyperactivity disorder: A meta-analysis of follow-up studies
Psychol Med
Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis
Br J Psychiatry
Neuroimaging of attention-deficit/hyperactivity disorder: Current neuroscience-informed perspectives for clinicians
Curr Psychiatry Rep
Toward systems neuroscience of ADHD: A meta-analysis of 55 fMRI studies
Am J Psychiatry
Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: Exploring task-specific, stimulant medication, and age effects
JAMA Psychiatry
Identifying a consistent pattern of neural function in attention deficit hyperactivity disorder: A meta-analysis
Psychol Med
Neuronal correlates of ADHD in adults with evidence for compensation strategies--A functional MRI study with a Go/No-Go paradigm
Ger Med Sci
Preliminary fMRI findings on the effects of event rate in adults with ADHD
J Neural Transm
Functional MRI reveals different response inhibition between adults and children with ADHD
Neuropsychology
Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modeling
J Neurosci
Definition and characterization of an extended social-affective default network
Brain Struct Funct
Cited by (30)
Common and Distinct Neural Patterns of Attention-Deficit/Hyperactivity Disorder and Borderline Personality Disorder: A Multimodal Functional and Structural Meta-analysis
2023, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingComparative research on neural dysfunction in children with dyslexia under different writing systems: A meta-analysis study
2022, Neuroscience and Biobehavioral ReviewsWhole-brain modelling of resting state fMRI differentiates ADHD subtypes and facilitates stratified neuro-stimulation therapy
2021, NeuroImageCitation Excerpt :Presumably, insular cortex is a key region of the salience network (Uddin, 2015) and it has been linked to impairment of executive functions in ADHD (Zhao et al., 2017). In addition to cortical regions, meta-analysis suggests involvement of subcortical regions as well (Cortese et al., 2016). Putamen is thought to be involved in the cortico-striatal circuit that has been linked to ADHD pathology (Bush et al., 2005).
Systematic Review and Meta-analysis: Resting-State Functional Magnetic Resonance Imaging Studies of Attention-Deficit/Hyperactivity Disorder
2021, Journal of the American Academy of Child and Adolescent PsychiatryBrain alterations in children/adolescents with ADHD revisited: A neuroimaging meta-analysis of 96 structural and functional studies
2019, Neuroscience and Biobehavioral ReviewsCitation Excerpt :We excluded the ones that did not meet our inclusion criteria (Supplemental Table S1). Although there are many available CBMA with significant consistent results in various neuropsychiatric disorders (Cortese et al., 2016, 2012; Goodkind et al., 2015; Herz et al., 2014; Radua et al., 2012; Tahmasian et al., 2017, 2016; Wegbreit et al., 2014), some previous meta-analyses in unipolar depression (Muller et al., 2017) and insomnia disorder (Tahmasian et al., 2018a, 2018b) investigated a large body of literature and followed the best-practice guideline (i.e., rigorous in-/exclusion criteria and statistical threshold), but still observed a lack of convergence across their sub-analyses. The authors suggested that small samples of participants, clinical variability, various experimental design, flexibility in preprocessing, and statistical approaches could be the possible reasons of observed heterogeneity in such disorder (Muller et al., 2017; Tahmasian et al., 2018a, 2018b).