Original articleP50 Suppression in Individuals at Risk for Schizophrenia: The Convergence of Clinical, Familial, and Vulnerability Marker Risk Assessment
Section snippets
Participants
Thirty-one individuals (aged 12–30 years) at risk for schizophrenia were recruited throughout the community of San Diego. The at-risk subjects were compared with 21 age-matched normal comparison subjects. All subjects provided written informed consent after the procedures were fully explained (UCSD IRB# 030829).
Recruitment and Assessment
Individuals classified as “at risk” for schizophrenia were identified through a broad community outreach program. Educational lectures regarding schizophrenia and the prodromal symptoms
Results
There were no statistically significant differences between groups in the amplitude [t(50) = .06, ns] or latency [t(50) = .7, ns] of the P50 response to the first stimulus or the amplitude [t(50) = −1.0, ns] or latency [t(35) = −.06, ns] of the P50 response to the second stimulus (see Figure 2) according to t tests. Nine of the 31 at-risk subjects and 6 of the 21 comparison subjects did not have an identifiable P50 response to the second stimulus (Fisher exact test, ns). The P50 suppression of
Discussion
At-risk individuals with a family history of schizophrenia in a first-degree relative have reduced P50 suppression compared with demographically matched normal comparison subjects, as well as with other individuals identified as being at risk for developing schizophrenia on the basis of subsyndromal or brief episodes of psychotic symptoms. As a group, individuals who have a familial risk and/or are clinically at risk for schizophrenia have reduced P50 ERP suppression and differ from normal
References (53)
- et al.
Clozapine, but not typical antipsychotics, correct P50 suppression deficit in patients with schizophrenia
Clin Neurophysiol
(2004) Vulnerability markers in the schizophrenia spectrumImplications for phenomenology, genetics, and the identification of the schizophrenia prodrome
Psychiatr Clin North Am
(2002)- et al.
P50 suppression among schizophrenia and normal comparison subjectsA methodological analysis
Biol Psychiatry
(1997) - et al.
Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects
Schizophr Res
(1998) - et al.
P50 abnormalities in schizophreniaRelationship to clinical and neuropsychological indices of attention
Schizophr Res
(1998) - et al.
Alternative phenotypes for the complex genetics of schizophrenia
Biol Psychiatry
(1999) - et al.
One year outcome in first episode psychosisInfluence of DUP and other predictors
Schizophr Res
(2002) - et al.
Developmental and genetic influences on the P50 sensory gating phenotype
Biol Psychiatry
(1996) - et al.
P50 sensory gating in adolescents from a pacific island isolate with elevated risk for schizophrenia
Biol Psychiatry
(2004) - et al.
Sensory gating in schizophrenics and normal controlsEffects of changing stimulation interval
Biol Psychiatry
(1989)
Gating of auditory response in schizophrenics and normal controls. Effects of recording site and stimulation interval on the P50 wave
Schizophr Res
Potential use of animal models to examine antipsychotic prophylaxis for schizophrenia
Clin Neurosci Res
Premenstrual mood changes and gating of the auditory evoked potential
Psychoneuroendocrinology
Psychosis prediction12-month follow up of a high-risk (“prodromal”) group
Schizophr Res
Scale for the Assessment of Negative Symptoms (SANS)
Scale for the Assessment of Positive Symptoms (SAPS)
The family history method using diagnostic criteriaReliability and validity
Arch Gen Psychiatry
Olanzapine effects on auditory sensory gating in schizophrenia
Am J Psychiatry
The Importance of Endophenotypes in Studies of the Genetics of Schizophrenia
Preattentional and attentional cognitive deficits as targets for treating schizophrenia
Psychopharmacology (Berl)
P50 event-related-potential sensory gating deficits in schizotypal personality disordered subjects
Am J Psychiatry
Neurobiological measures of schizotypal personality disorderDefining an inhibitory endophenotype?
Am J Psychiatry
Quantitative neural indicators of liability to schizophreniaImplications for molecular genetic studies
Am J Med Genet
Poor P50 suppression among schizophrenia patients and their first-degree biological relatives
Am J Psychiatry
The earth is round
Am Psychol
The schizophrenia prodrome revisitedA neurodevelopmental perspective
Schizophr Bull
Cited by (67)
Auditory event-related electroencephalographic potentials in borderline personality disorder
2022, Journal of Affective DisordersCitation Excerpt :Moreover, Grootens et al. (2008) reported a significantly greater difference between P50 for S1 and P50 for S2 in BPD patients as compared to HC, which was mainly due to a greater S1 response. P50 sensory gating is implied in the ability to filter the relevant stimulus at a pre-attentional level and its reduction was frequently identified in schizophrenic patients (Hamilton et al., 2018; Shen et al., 2020), making it a possible marker of vulnerability to psychosis (Cadenhead et al., 2005; Olincy and Martin, 2005). Therefore, the reduced P50 sensory gating observed by Niemantsverdriet et al. (2019) in BPD patients with AVH could indicate a vulnerability to psychosis.
Forecasting psychosis by event-related potentials - Systematic review and specific meta-analysis
2015, Biological PsychiatrySensory gating deficits in the attenuated psychosis syndrome
2015, Schizophrenia Research