Short communicationInfusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors
Section snippets
Contributions
F.H.M., R.R.S., R.M.B and J.A.K. designed and conducted all experiments. F.H.M and R.R.S. wrote the manuscript. R.N.T. supervised the project. All authors edited and accepted the final version of the manuscript.
Acknowledgments
This research was supported by CAPES, PRONEX, FAPESC and CNPq from which F.H.M., R.R.S, R.M.B. and J.A.K. received doctoral fellowship and R.N.T. a research fellowship. The authors would like to thank Dr. Antonio de Padua Carobrez for help with the experimental design and Jose Rodriguez-Romaguera for critical reading of the manuscript and helpful suggestions.
References (39)
- et al.
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
Trends in Pharmacological Sciences
(2009) - et al.
Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it
Neuroscience
(2012) - et al.
Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction
Neuroscience
(2008) - et al.
Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats
European Neuropsychopharmacology
(2008) - et al.
Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneurons
Neuroscience
(2001) - et al.
Cannabinoid CB1 receptors in rat medial prefrontal cortex are colocalized with calbindin- but not parvalbumin- and calretinin-positive GABA-ergic neurons
Pharmacological Reports
(2009) - et al.
Impairment of contextual conditioned fear extinction after microinjection of alpha-1-adrenergic blocker prazosin into the medial prefrontal cortex
Behavioural Brain Research
(2010) - et al.
Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats
Behavioural Brain Research
(2010) - et al.
Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects
Biochemical Pharmacology
(2003) - et al.
Cannabinoid facilitation of fear extinction memory recall in humans
Neuropharmacology
(2013)
Prefrontal control of fear: more than just extinction
Current Opinion in Neurobiology
(2010)
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Neuroscience
(1998)
Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test
Progress in Neuro-Psychopharmacology & Biological Psychiatry
(2006)
Cannabidiol – recent advances
Chemical Biodiversity
(2007)
Targeting the endocannabinoid system: to enhance or reduce
Nature Reviews Drug Discovery
(2008)
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
British Journal of Pharmacology
(2001)
Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
Neuropsychopharmacology
(2005)
The role of prefrontal cortex CB1 receptors in the modulation of fear memory
Cerebral Cortex
(2009)
The endogenous cannabinoid system controls extinction of aversive memories
Nature
(2002)
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These authors contributed equally to this work.
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