Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
PrefaceChemistry and mechanism of phosphatases, diesterases and triesterases
Section snippets
Alvan C. Hengge was born and grew up in Cincinnati, Ohio. After obtaining his B.S. from the University of Cincinnati he taught high school chemistry and physics from 1975 to 1982 at Robert A. Taft High School. He then returned to the University of Cincinnati for graduate school, obtaining a Ph. D. in Organic Chemistry in 1987 in the laboratory of R. Marshall Wilson studying the reactions of triazolinedione ylides. This was followed by an NIH postdoctoral fellowship in the lab of W. W. Cleland
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The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases
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Cited by (2)
Agrobacterium rhizogenes rolB oncogene: An intriguing player for many roles
2021, Plant Physiology and BiochemistryCitation Excerpt :Phosphatases are some of the most efficient enzymes, that can catalyze the hydrolysis of different, but related, substrates. Such “catalytic promiscuity” could have paved the way for the evolution of new enzymatic activities (Hengge, 2013), exploited by RolB to extend the range of its abilities. A clue on the possible function of rolB in the production of adventitious roots came from the work by Moriuchi et al. (2004) in tobacco, where direct binding of the RolB protein from the A. rhizogenes mikimopine strain 1724 to a protein of the 14-3-3 family, Nt14-3-3, was observed.
Phosphoryl transfers of the phospholipase D superfamily: A quantum mechanical theoretical study
2013, Journal of the American Chemical Society
Alvan C. Hengge was born and grew up in Cincinnati, Ohio. After obtaining his B.S. from the University of Cincinnati he taught high school chemistry and physics from 1975 to 1982 at Robert A. Taft High School. He then returned to the University of Cincinnati for graduate school, obtaining a Ph. D. in Organic Chemistry in 1987 in the laboratory of R. Marshall Wilson studying the reactions of triazolinedione ylides. This was followed by an NIH postdoctoral fellowship in the lab of W. W. Cleland at the University of Wisconsin in the Institute for Enzyme Research, where he studied the biochemistry and enzymology of phosphoryl and acyl transfer. This was followed by several years as an Assistant Scientist in the Cleland laboratory. He joined the faculty at Utah State University in 1996, where he is now a Professor in the Department of Chemistry and Biochemistry, and has been Department Head since 2009. His research focuses on investigations, through the eyes of a chemist, of the mechanisms of biologically important reactions, particularly phosphate and sulfate ester chemistry. He has authored a number of reviews on phosphoryl transfer, including articles in Chemical Reviews; Accounts of Chemical Research; Comprehensive Natural Products II: Chemistry and Biology; Advances in Physical Organic Chemistry; and the Encyclopedia of Catalysis.