Singlet oxygen formation in monomeric and aggregated porphyrin c

doi:10.1016/1011-1344(89)80022-3

Journal of Photochemistry and Photobiology B: Biology

Volume 3, Issue 1, February 1989, Pages 81-89

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Abstract

The absorption and fluorescence spectra of monomeric and aggregated species present in aqueous solutions of porphyrin c have been resolved by steady-state and time-resolved spectroscopy. The dependence of the singlet oxygen formation yield φΔ on excitation wavelength has also been determined. In the Q-band spectral region, the aggregate absorption and emission spectra are shifted to longer wavelengths with respect to the monomer spectrum with φΔ (monomer)= 0.59 and φΔ(aggregate) = 0.33. The relevance of these findings to the optimization of irradiation conditions in tumour phototherapy using porphyrin c are discussed.

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Singlet oxygen formation in monomeric and aggregated porphyrin c

Abstract

Photobiochem. Photobiophys.

Chem. Phys.

J. Chem. Soc., Faraday Trans. II

Porphyrin-protein bond of cytochrome c. Structure of porphyrin c

J. Am. Chem. Soc.

Photochemical properties of porphyrin c: an agent for use in tumor phototherapy

Photochem. Photobiol.

Porphyrin c: a compound for use in phototherapy of tumors with no significant generalized photosensitivity

The binding of porphyrins by ligandin

Biochem. J.

Singlet oxygen production by UV and visible photoexcited porphyrins under different states of aggregation

Photobiochem. Photobiophys.

Photomodification of biological membranes with emphasis on singlet oxygen mechanisms

Photochem. Photobiol.