The MAP kinase cascade is essential for diverse signal transduction pathways

doi:10.1016/0968-0004(93)90019-J

Trends in Biochemical Sciences

Volume 18, Issue 4, April 1993, Pages 128-131

https://doi.org/10.1016/0968-0004(93)90019-J Get rights and content

Abstract

Mitogen-activated protein (MAP) kinases are activated by combined tyrosine and threonine phosphorylation catalysed by MAP kinase kinase, a novel class of protein kinases with dual specificity for both tyrosine and serine/threonine. MAP kinase kinase is turned on by serine/threonine phosphorylation catalysed by an immediate upstream kinase. The MAP kinase cascade appears to be conserved during evolution and thus might play an essential role in diverse intracellular signaling processes from yeasts to vertebrates.

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Trends in Biochemical Sciences

ReviewThe MAP kinase cascade is essential for diverse signal transduction pathways

Abstract

J. Biol. Chem.

Int. Rev. Cytol.

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

FEBS Lett.

J. Biol. Chem.

J. Biol. Chem.

Cell

J. Biol. Chem.

J. Biol. Chem.

Nature

Mol. Cell. Biol.

Mol. Cell. Biol.

Biochim. Biophys. Acta

Cell Regul.

Cell

Science

Nature

Review
The MAP kinase cascade is essential for diverse signal transduction pathways