Molecular basis of chromosome movement: Current Opinion in Structural Biology 1992, 2:275–279

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Abstract

At mitosis, a large complex of proteins is assembled onto centromeric DNA sequences to form kinetochores. These structures attach to microtubules and generate force for chromosome movement. Recent experiments have shown that the mechanism of chromosome movement involves both the action of motor proteins and microtubule polymerization and depolymerization at kinetochores.

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