Topographic maps and molecular gradients

doi:10.1016/0959-4388(93)90037-Y

Current Opinion in Neurobiology

Volume 3, Issue 1, February 1993, Pages 67-74

https://doi.org/10.1016/0959-4388(93)90037-Y Get rights and content

Abstract

Topographically organized patterns of connectivity occur throughout the central and peripheral nervous systems. It is commonly supposed that gradients of recognition molecules underlie this form of synaptic specificity. Recent studies have led to new ideas about how such gradients might arise in the retinotectal system, and initiated molecular analyses of position-dependent gene expression in the peripheral motor system.

References (51)

B. Stahl et al.
Biochemical Characterization of a Putative Axonal Guidance Molecule of the Chick Visual System
Neuron
(1990)
N.H. Patel et al.
Expression of engrailed Proteins in Arthropods, Annelids, and Chordates
Cell
(1989)
R.M. Alvarado-Mallart et al.
Pluripotentiality of the 2-Day-Old Avian Germinative Neuroepithelium
Dev Biol
(1990)
S. Martinez et al.
Expression of the Homeobox Chick-en Gene in Chick/Quail Chimeras with Inverted Mes-Metencephalic Grafts
Dev Biol
(1990)
S. Martinez et al.
Induction of a Mesencephalic Phenotype in the 2-Day-Old Chick Prosencephalon is Preceded by the Early Expression of the Homebox Gen en
Neuron
(1991)
T. Matsuno et al.
Regulation of the Rostrocaudal Axis of the Optic Tectum: Histological Study After Rostrocaudal Rotation in Quail-Chick Chimeras
Dev Brain Res
(1991)
R. Nusse et al.
Wnt Genes
Cell
(1992)
P. McCaffery et al.
Aldehyde Dehydrogenase is a Positional Marker in the Retina
Development
(1991)
P. McCaffery et al.
Asymmetrical Retinoic Acid Synthesis in the Dorsoventral Axis of the Retina
Development
(1992)
M.B. Laskowski et al.
Topographic Mapping of Motor Pools Onto Skeletal Muscles
J Neurosci
(1987)

J.W. Lichtman et al.

On the Purpose of Selective Innervation of Guinea-Pig Superior Cervical Ganglion Cells

J Physiol

(1979)

J.N. Langley

On the Regeneration of Pre-Ganglionic and of Post-Ganglionic Visceral Nerve Fibres

J Physiol

(1897)

T. Mitamura et al.

The 27-kd Diphtheria Toxin Receptor-Associated Protein (DRAP27) from Vero Cells is the Monkey Homologue of Human CD9 Antigen: Expression of DRAP27 Elevates the Number of Diphtheria Toxin Receptors on Toxin-Sensitive Cells

J Cell Biol

(1992)

M.J. Donoghue et al.

A Rostrocaudal Gradient of Transgene Expression in Adult Skeletal Muscle

S.B. Udin et al.

Formation of Topographic Maps

Anna Rev Neurosci

(1988)

R.W. Sperry

Chemoaffinity in the Orderly Growth of Nerve Fiber Patterns and Connections

G.D. Trisler et al.

A Topographic Gradient of Molecules in Retina can be Used to Identify Neuron Position

M. Constantine-Paton et al.

A Cell Surface Molecule Distributed in a Dorsoventral Gradient in the Perinatal Rat Retina

Nature

(1986)

S.A. RaBacchi et al.

A Positional Marker for the Dorsal Embryonic Retina is Homologous to the High-Affinity Laminin Receptor

Development

(1990)

S.C. McLoon

A Monoclonal Antibody that Distinguishes Between Temporal and Nasal Retinal Axons

J Neurosci

(1991)

D. Trisler

Cell Recognition Molecules and Pattern Formation in the Developing Visual System

J. Walter et al.

Recognition of Position-Specific Properties of Tectal Cell Membranes by Retinal Axons In Vitro

Development

(1987)

H. Baler et al.

Axon Guidance by Gradients of a Target-Derived Component

Science

(1992)

C.A. Gardner et al.

Expression of an engrailed-Like Gene During Development of the Early Embryonic Chick Nervous System

J Neurosci Res

(1988)

C.A. Davis et al.

Examining Pattern Formation in Mouse, Chicken and Frog Embryos with an en-Specific Antiserum

Development

(1991)

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View full text

Topographic maps and molecular gradients

Abstract

Neuron

Cell

Dev Biol

Dev Biol

Neuron

Dev Brain Res

Cell

Development

Development

J Neurosci

J Physiol

J Physiol

J Cell Biol

Formation of Topographic Maps

Anna Rev Neurosci

Chemoaffinity in the Orderly Growth of Nerve Fiber Patterns and Connections

A Topographic Gradient of Molecules in Retina can be Used to Identify Neuron Position

A Cell Surface Molecule Distributed in a Dorsoventral Gradient in the Perinatal Rat Retina

Nature

A Positional Marker for the Dorsal Embryonic Retina is Homologous to the High-Affinity Laminin Receptor

Development

A Monoclonal Antibody that Distinguishes Between Temporal and Nasal Retinal Axons

J Neurosci

Cell Recognition Molecules and Pattern Formation in the Developing Visual System

Recognition of Position-Specific Properties of Tectal Cell Membranes by Retinal Axons In Vitro

Development

Axon Guidance by Gradients of a Target-Derived Component

Science

Expression of an engrailed-Like Gene During Development of the Early Embryonic Chick Nervous System

J Neurosci Res

Examining Pattern Formation in Mouse, Chicken and Frog Embryos with an en-Specific Antiserum

Development