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Increased frequency of aberrant CSF circulation in schizophrenic patients compared to healthy volunteers

Published online by Cambridge University Press:  16 April 2020

G Oxenstierna ,
G Bergstrand ,
G Edman ,
L Flyckt ,
H Nybäck  and
G Sedvall
G Oxenstierna
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
G Bergstrand
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
G Edman
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
L Flyckt
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
H Nybäck
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
G Sedvall
Affiliation:
Department of Clinical Neuroscience, Psychiatry and Psychology Section, Karolinska Hospital, S-17176Stockholm, Sweden
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Summary

In a previous cisternographic study of the cerebrospinal fluid (CSF) circulation in schizophrenic patients, indications for disturbed flow dynamics were found in 10 of 30 subjects. In order to replicate and investigate the clinical and pathophysiological significance of this finding, 39 schizophrenic patients and 42 healthy subjects were examined with an improved method for measurement of CSF circulation. 99mTc-DTPA was injected intrathecally and the gamma cisternograms were evaluated blindly. Correlations between cisternography findings and age, duration of disease, previous hospitalizations, positive or negative symptomatology, exposure to neuroleptics, psychiatric family history, CT findings and CSF levels of protein, tryptophan and monoamine metabolites, were calculated. Seven of the patients showed abnormalities in the cisternograms with a slow or obstructed flow of CSF over the convexities (P < 0.01) whereas none of the healthy volunteers showed abnormalities. There were no correlations between disturbed CSF circulation in the patients and the clinical and biochemical parameters, thus the significance of the deviations, similar to other biological aberrations found in schizophrenic patients, is not known. Recent developments in magnetic resonance imaging offer new possibilities to further examine CSF circulation abnormalities in schizophrenia.

Keywords

schizophreniaCSF circulationgamma-cisternographyTc-DTPA
Type
Original article
Information
European Psychiatry , Volume 11 , Issue 1 , 1996 , pp. 16 - 20
Copyright
Copyright © 1996 Elsevier, Paris

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