European Journal of Pharmacology: Molecular Pharmacology
Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes
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2020, The Lancet Infectious DiseasesAn orthologue of the host-defense protein psoriasin (S100A7) is expressed in frog skin
2017, Developmental and Comparative ImmunologyCitation Excerpt :This was added to serial twofold protein dilutions of R. temporaria RtS100A7 ranging from 128 μM to 0.125 μM. As a positive control, serial twofold dilutions of synthetic magainin 2 (CASLO Laboratory ApS, Lyngby, Denmark), a host-defense peptide from the frog Xenopus laevis known to permeabilize bacterial membranes and cause cell lysis (Cruciani et al., 1992; Ludtke et al., 1996; Matsuzaki et al., 1997), were tested in parallel (128 μM–0.125 μM). Fluorescence was measured during incubation at 37 °C in a multi-mode microplate reader (Synergy™ Mx Monochromator-Based Multi-Mode Microplate Reader, BioTek Instruments, Inc.) using an excitation wavelength of 488 nm and an emission wavelength of 523 nm.
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Current address: Div. Human Genetics and Molecular Biology. Childrens Hospital of Philadelphia, Philadelphia, PA, USA.