Research reportEpileptic focus induced by intrahippocampal cholera toxin in rat: time course and properties in vivo and in vitro
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Focally Applied Chemoconvulsants
2017, Models of Seizures and Epilepsy: Second EditionInhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats
2010, NeuropharmacologyCitation Excerpt :Although the role of AC in the epileptogenesis of AGS kindling has not been unequivocally established in the present study, the permanence of the mimicry of AGS kindling induced by one-time bilateral microinjection of an AC activator into the lateral amygdala (Tupal and Faingold, 2010) would support the probable role of AC in the kindling process. Evidence from previous studies also show that similar downstream activation of AC via different mechanisms involving G-protein-coupled receptors in other brain areas may lead to the emergence of seizures and also contribute to pharmacoresistent epilepsy (Williams et al., 1993; Rocha et al., 2009). Therefore, future studies are needed to better understand the role of the NMDA receptor-mediated AC-dependent signal transduction in the epileptogenic mechanisms of AGS kindling, including evaluation of the ability of AC inhibitors, such as SQ22,536, to block the production of precipitous AGS kindling inducible by an AC activator in vivo (Tupal and Faingold, 2010), as well as ex vivo amygdala slice electrophysiology evaluation of these mechanisms.
Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex
2009, Neurobiology of DiseaseCitation Excerpt :The cyclic AMP (cAMP) has been postulated to be involved in the pathophysiology of seizure disorders (Ludvig and Moshé, 1989; Ludvig et al., 1992). Stimulation of AC or cAMP induces proconvulsant effects (Higashima et al., 2002; Williams et al., 1993; Yokoyama et al., 1989), whereas some antiepileptic drugs, such as carbamazepine, inhibit AC activity and downstream effects of AC activation (Chen et al., 1996). Chronic opioid exposure results in elevated cAMP and AC activity (Sharma et al., 1975, Collier, 1980; Duman et al., 1988, Nestler, 1997), as well as enhanced efficacy of excitatory opioid receptor activation of the Gs/AC/cAMP system (Wang and Gintzler, 1995; Wu et al., 1995).
Did all those famous people really have epilepsy?
2005, Epilepsy and BehaviorLow frequency stimulation modifies receptor binding in rat brain
2004, Epilepsy Research