Neuron
Volume 9, Issue 5, November 1992, Pages 929-942
Journal home page for Neuron

Article
The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

https://doi.org/10.1016/0896-6273(92)90245-9Get rights and content

Abstract

In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre-and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-I (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dig and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.

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