ArticleBranched chain amino acids improve radial-arm maze acquisition and water maze forced-choice learning in rat offspring exposed in utero to hyperphenylalaninemia
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2016, Neurotoxicology and TeratologyCitation Excerpt :In another experiment on the postnatal effects of hyperphenylalaninemia with and without branched chain amino acid treatment, different offspring per litter were tested in the CWM with 2 trials/day in path-A and 2 trials/day in path-B for 3 days each, but half the offspring had a 5 min/trial time limit and half had a 6 min/trial time limit. A small interaction of treatment × sex × trial × time limit on path-A was found (only in males and only on 2 of the 6 path-A trials), but no such effect was found on path-B. Overall, this suggested that the trial time limit difference had only a minor effect (Vorhees et al., 1992). Therefore, we adopted the 5 min trial limit in subsequent experiments.
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