Molecular mapping of the mouse ob mutation

doi:10.1016/0888-7543(91)90032-A

Genomics

Volume 11, Issue 4, December 1991, Pages 1054-1062

https://doi.org/10.1016/0888-7543(91)90032-A Get rights and content

Abstract

The mouse ob mutation has been mapped relative to a series of RFLPs among the progeny of three separate mouse crosses: an intraspecific backcross, an intraspecific intercross, and an interspecific intercross. Genotypic assignment at the ob locus was made by making use of measurements of body mass index and the plasma concentrations of glucose and insulin. These data have suggested that the development of diabetes in these animals is a consequence of unlinked polygenes. There was also evidence that unlinked Mus spretus alleles can diminish the obesity of $ob ob$ mice. From these data we have mapped several markers on chromosome 6 with the following order: cen-Cola-2-Met-ob-Cpa-Tcrb. The homologs of markers that flank ob map to human chromosome 7q, suggesting that if there is a human homologue of ob, it maps to 7q31.

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Genomics

Abstract

References (29)

Chromosomal localization of the met protooncogene in the mouse and cat genome

Genomics

A genetic linkage map of the human genome

Cell

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

Anal. Biochem

Cellularity of adipose tissue depots in six strains of genetically obese mice

J. Lipid. Res

Indices of relative weight and obesity

J. Chronic Dis

Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts

J. Biol. Chem

Maps of linkage and synteny homologies between mouse and man

Trends Genet

Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse cross

EMBO J

Genetic analysis of the mouse using interspecific crosses

Trends Genet

Molecular mapping of the mouse db mutation

Obese and Diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

Diabetologia

Diabetes-obesity syndromes in mice

Diabetes

Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers

Israel J. Med. Sci

Recombination percentages

Cited by (162)

Adipokines in obesity and metabolic-related-diseases

Bone glycolysis and the regulation of energy balance

Trajectory of leptin and leptin receptor in vertebrates: Structure, function and their regulation

Animal models of ingestive behaviors

Sanhuang Jiangtang tablet protects type 2 diabetes osteoporosis via AKT-GSK3β-NFATc1 signaling pathway by integrating bioinformatics analysis and experimental validation

Basic Principles of Drug Discovery and Development

Regular articleMolecular mapping of the mouse ob mutation

Abstract

Genomics

Cell

Anal. Biochem

J. Lipid. Res

J. Chronic Dis

J. Biol. Chem

Trends Genet

Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse cross

EMBO J

Genetic analysis of the mouse using interspecific crosses

Trends Genet

Molecular mapping of the mouse db mutation

Obese and Diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

Diabetologia

Diabetes-obesity syndromes in mice

Diabetes

Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers

Israel J. Med. Sci

Recombination percentages

Regular article
Molecular mapping of the mouse ob mutation