ArticleEffect of ethanol on amino acids and related compounds in rat plasma, heart, aorta, bronchus, and pancreas
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2017, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Pretreating rats with carnosine before ethanol exposure leads to an acceleration in the recovery from oxidative damage; this is seen both biochemically and histologically [26]. After acute treatment with ethanol (2 g/kg injected intraperitoneally), no changes in the levels for carnosine were observed in plasma, although and increase of this metabolite was observed in heart tissue [27], this being in accordance to what was observed in plasma (in A vs S) in this work. Regarding the polyamine spermidine, Zaitsu et al. observed an increase of this metabolite with respect to the control group in cocaine-treated rats (10 mg/kg intraperitoneal injection) in plasma [12].
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2012, Journal of Biological ChemistryCitation Excerpt :It has been previously noted that the intracellular level of amino acids can be refractory to changes in the level of extracellular amino acids (74). Studies in rats (75, 76) have shown that ethanol and fasting can produce significant changes in the levels of amino acids and related compounds in plasma and various tissues. However, the changes in tissue amino acid levels were found to be highly tissue-specific and generally unrelated to changes seen in the plasma.
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