Elsevier

Hearing Research

Volume 12, Issue 2, November 1983, Pages 185-197
Hearing Research

Residual effects in monaural temporary threshold shifts to pure tones

https://doi.org/10.1016/0378-5955(83)90105-3Get rights and content

Abstract

Temporary threshold shifts (TTS), of the cochlear action potential in the guinea pig, caused by a high frequency exposure tone could be reduced by a prior exposure at the same frequency but lower intensity. The TTS caused by the initial, low intensity exposure tone was allowed to recover to levels where the thresholds were not significantly different from normal thresholds. Re-exposure at the high intensity now resulted in less TTS being recorded, both at the half-octave point and across the range of frequencies affected by the pure tone, when compared to exposure to the high intensity tone without such priming. This protective effect of prior exposure was not affected by intraperitoneal injections of strychnine, distinguishing it from recent reports of protective mechanisms operative during TTS.

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Cited by (20)

  • Follow-up of latency and threshold shifts of auditory brainstem responses after single and interrupted acoustic trauma in guinea pig

    2009, Brain Research
    Citation Excerpt :

    Results from two different protocols support this view. First, “conditioning protocols,” i.e., pre-exposing subjects to the acoustic stimuli at a lower non-traumatic level, were shown to protect from the damaging effects of high-level stimulation (Rajan and Johnstone, 1983; Canlon et al., 1988; Campo et al., 1991; Ryan et al., 1994; Zuo et al., 2008). Second, results from “interrupted repetitive protocols” revealed that the threshold shift induced by a traumatic sound during the initial days of exposure gradually recovers during the following days of exposure, a phenomenon described as the “toughening” effect (Miller et al., 1963; Clark et al., 1987; Subramaniam et al., 1991a).

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