Elsevier

Gene

Volume 74, Issue 1, 25 December 1988, Pages 129-133
Gene

Promoter inhibition by DNA methylation: a reversible signal

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    DNA methylation is one essential component of epigenetics, exerting direct control over gene expression through the organisation of local chromatin structure for the allowance or blockage of access by transcriptional machinery [15]. Importantly, epigenetic processes such as DNA methylation are reversible with drug treatments, making these compounds a possible therapeutic agent [16]. It has previously been demonstrated that CYP19A1 transcription can be epigenetically regulated.

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Presented at the New England Biolabs Workshop on Biological DNA Modification, Gloucester, MA (U.S.A.) 20–23 May 1988.

∗∗

Present address: INSERM-CNRS, Centre d'Immunologie,70 Route L. Lachamp, Case 906, Marseille 13288 (France) Tel. (91)269477; (U.M.) Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544 (U.S.A.) Tel.(609)452-5993; (U.L.) Department of Microbiology and Immunology, University of California School of Medicine, San Francisco, CA 94143 (U.S.A.)Tel. (415)476-2824.

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