The possibility of producing the H-dibaryon (H0) in proton-nucleus collisions is investigated. Quantitative estimates of the H0 production rate in p-A collisions are obtained using the RQMD cascade model assuming the H0's are produced through coalescence of ΛΛ and ΞN pairs. The H0 rapidity distribution is shown, and the impact of the kinematics of H0 production in p-A collisions on existing and future experiments is discussed.