Effects of systemic clonidine on auditory event-related potentials in squirrel monkeys

doi:10.1016/0361-9230(94)90051-5

Brain Research Bulletin

Volume 33, Issue 1, 1994, Pages 79-86

https://doi.org/10.1016/0361-9230(94)90051-5 Get rights and content

Abstract

Event-related potential (ERP), electroencephalographic (BEG), and behavioral data were collected from squirrel monkeys (Saimiri sciureus) in a 90−10 auditory oddball paradigm. Background or target tones were presented once every 2 s, and responses to the targets were rewarded. ERPs were recorded from epidural electrodes following systemic administration of clonidine (0.1 mg/kg) or a saline placebo. EEG power spectra and behavioral performance were assessed simultaneously as indices of behavioral state. Clonidine significantly decreased the area and increased the latency of a P300-like potential. The amplitudes and areas of the earlier P1, N1, and P2 components and a later slow wave-like potential were not reduced, nor were their latencies altered. Clonidine produced increased EEG power in the alpha range (7.5–12 Hz) and decreased power in the upper beta range (20–40 Hz) but did not affect performance in the oddball task. Because two major effects of clonidine are to substantially reduce activity in the noradrenergic nucleus locus coeruleus (LC) and to reduce norepinephrine (NE) release from axons, the present results support the hypothesis that the LC and its efferent projection system are important in modulating the activity of P300-like potentials.

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Effects of systemic clonidine on auditory event-related potentials in squirrel monkeys

Abstract

Electroencephalogr. Clin. Neurophysiol.

Eur. J. Pharmacol.

Exp. Neurol.

Brain Res. Bull.

Electroencephalogr. Clin. Neurophysiol.

Psychiatr. Res.

Electroencephalogr. Clin. Neurophysiol.

Brain Res.

Brain Res. Bull.

Brain Res.

Electroencephalogr. Clin. Neurophysiol.

Electroencephalogr. Clin. Neurophysiol.

Brain Res. Bull.

Brain Res.

Eur. J. Pharmacol.

Electroencephalogr. Clin. Neurophysiol.

Electroencephalogr. Clin. Neurophysiol.

Electroencephalogr. Clin. Neurophysiol.

Electroencephalogr. Clin. Neurophysiol.

Neuropsychologia

Brain Res.

Electroencephalogr. Clin. Neurophysiol.

Task-relevant late positive component of the auditory event-related potential in monkeys resembles P300 in humans

Science

Behavioral functions of locus coeruleus derived from cellular attributes

Physiol. Psychol.

Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle

J. Neurosci.

Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli

J. Neurosci.

Anatomical evidence for alpha-2 adrenoceptor heterogeneity: Differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain

J. Pharmacol. Exp. Ther.

Endogenous auditory potentials in the cat: A P300 model

Evidence that locus coeruleus is the site where clonidine and drugs acting at alpha-1 and alpha-2 adrenoceptors affect sleep and arousal mechanisms

Br. J. Pharmacol.