Effects of the novelty or familiarity of visual stimuli on the expression of the immediate early gene c-fos in rat brain

doi:10.1016/0306-4522(95)00320-I

Neuroscience

Volume 69, Issue 3, December 1995, Pages 821-829

https://doi.org/10.1016/0306-4522(95)00320-I Get rights and content

Abstract

To investigate substrates of recognition memory, the cellular expression of Fos protein in rat brain has been studied after groups of rats were either shown sets of novel or highly familiar objects, or were exposed to the same pattern of illumination without objects being shown. Counts of stained nuclei were made in eight brain regions, where information about novel or familiar visual stimuli is likely to be processed or stored. The counts were relatively high in occipital visual association cortex and area TE of temporal cortex, intermediate in perirhinal cortex, entorhinal cortex, anterior cingulate cortex and the diagonal band of Broca, and low in the hippocampal formation and mediodorsal nucleus of the thalamus. The number of Fos-stained cells was significantly higher for the rats shown novel objects than for those shown familiar objects in perirhinal cortex, area TE, occipital cortex and anterior cingulate cortex.

Arguments are advanced that these differences in counts indicate areas involved in the processing and/or storage of information about the novelty or familiarity of visual stimuli, information important to recognition memory.

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Effects of the novelty or familiarity of visual stimuli on the expression of the immediate early gene c-fos in rat brain

Abstract

Behav. Brain Res.

Behav. Brain Res.

Neuroscience

Prog. Brain Res.

Molec. Brain Res.

Trends Neurosci.

Molec. Brain Res.

Neuron.

Prog. Neurobiol.

Neurosci. Lett.

Brain Res.

Memory impairments following restricted medial thalamic lesions in monkeys

Expl Brain Res.

The expression of the immediate-early genes c-fos, egr-1 and c-jun in the accessory olfactory bulb during the formation of an olfactory memory in mice

Neuroscience

Neuronal activity related to visual recognition memory: long-term memory and the encoding of recency and familiarity information in the primate anterior and medial inferior temporal and rhinal cortex

Expl Brain Res.

Monkeys (Macaca fascicularis) with rhinal cortex ablations succeed in object discrimination learning despite 24-hour intervals and fail at matching to sample despite double sample presentations

Behav. Neurosci.

Dissociated effects of perirhinal cortex ablation, fornix transection and amygdalectomy: evidence for multiple memory systems in the primate temporal lobe

Expl Brain Res.

Human Organic Memory Disorders

Learning-related changes in Fos-like immunoreactivity in the chick forebrain after imprinting