Endogenous levels of histidine in histamine-containing neurons and other identified nerve cells of Aplysia californica

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Abstract

1. Histidine was measured in single identified neurons isolated from the five major ganglia of Aplysia californica.

2. All neurons assayed appear to contain similar concentrations of histidine, approx 15 pmole/μg of cellular protein or about 3–4 mM.

3. The concentration of histidine in the hemolymph fluid, 63 μM, was significantly lower than in nerve cells indicating that Aplysia neurons may actively accumulate this amino acid.

4. In the histamine-containing neurons the concentration of histidine was not substantially different from the values of histidine obtained from neurons devoid of measurable histamine.

5. The presence of similar concentrations of histidine in such functionally and biochemically distinct neurons as those assayed in the present study indicates that the steady-state levels of histidine provide little insight into the function of Aplysia neurons.

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