General paper
Organ-specific distribution of isozymes of 5′-nucleotide phosphodiesterase in mouse

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Abstract

  • 1.

    1. The distribution of isozymes of 5′-nucleotide phosphodiesterase (E.C. 3.1.4.1) was examined in various organs of mouse, including liver, spleen, pancreas, heart, lung, kidney, brain and blood.

  • 2.

    2. Five isozymes were identified and designated as isozymes I through V.

  • 3.

    3. These isozymes are distributed unevenly with respect to the various organs and clear differences were observed in the patterns of distribution among the organs examined.

  • 4.

    4. The level of these isozymes was compared in serum of neonate and adut mice, and a higher level of isozyme I and a lower level of isozyme IV were found in neonates compared to adults.

  • 5.

    5. These results suggest that each isozyme has different functional roles in individual organs and that these isozymes may be involved in proliferation and development of cells.

References (23)

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    Nucleotide pyrophosphatase and phosphodiesterase. I. Organ distribution and activities in body fluid

    Clin. Chem.

    (1977)

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    Copyright © 1990 Published by Elsevier Inc.