Experimental peripheral neuropathy decreases the dose of substance P required to increase excitatory amino acid release in the CSF of the rat spinal cord
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Cited by (34)
Analgesic effect and related amino acids regulation of ginsenoside Rg3 in mouse pain models
2019, Life SciencesCitation Excerpt :Excitatory amino acids (EAAs), including aspartate (Asp) and glutamate (Glu), bind to the corresponding receptors in postsynaptic membrane to produce excitatory postsynaptic potential (EPSP), thus causing postsynaptic depolarization, so transmitting pain [21]. Levels of EAAs in the spinal cord and brain are significantly higher in pain models than normal animals [22,23]. Inhibitory amino acids (IAAs) including glycine (Gly), taurine (Tau) and γ-aminobutyric acid (GABA) work as the counterpart of EAAs which produce a hyperpolarisation effect due to inhibitory postsynaptic potential (IPSP).
Botulinum toxin type a (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction
2009, NeuroscienceCitation Excerpt :It is widely acknowledged that persistent hyperexcitability of primary sensory neurons is a major contributor to the development and maintenance of neuropathy behaviors in rodent models of peripheral nerve constriction (reviewed in Gold, 2000; Devor, 2006; Dray, 2008). The demonstrated increases in neurotransmitter release from hyperexcitable afferents within the dorsal horn (Skilling et al., 1992; Mark et al., 1998; Gardell et al., 2003; Coderre et al., 2005) and at the peripheral injury sites (Ma and Quirion, 2006) are also thought to contribute to neuropathic pain, particularly to peripheral and central sensitization. Here we demonstrated that the somata of TRG neurons ipsilateral to IoNC exhibit exaggerated vesicular release of FM4-64.
Pronociceptive actions of dynorphin via bradykinin receptors
2008, Neuroscience LettersChapter 5.5 Microdialysis in pain research
2006, Handbook of Behavioral NeuroscienceMicrodialysis in pain research
2003, Advanced Drug Delivery Reviews