Alterations in opiate receptor binding in MPTP-induced hemiparkinsonian monkeys

doi:10.1016/0304-3940(91)90783-P

Neuroscience Letters

Volume 127, Issue 2, 24 June 1991, Pages 155-159

https://doi.org/10.1016/0304-3940(91)90783-P Get rights and content

Abstract

Quantitative autoradiography was used to study [³H]naloxone binding in the striatum of normal monkeys and monkeys made hemiparkinsonian by the unilateral infusion of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The density of [³H]naloxone binding sites was significantly higher in the caudate and putamen on the MPTP-treated side of hemiparkinsonian monkeys, as compared with binding on the untreated side and in the striatum of normal monkeys. A more extensive patchy distribution of binding sites was evident throughout the striatum on the MPTP-treated side than seen in the striatum of the untreated side or in normal striatum.

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Alterations in opiate receptor binding in MPTP-induced hemiparkinsonian monkeys

Abstract

Brain Res.

Life Sci.

Life Sci.

Life Sci.

Brain Res.

Brain Res. Bull.

Brain Res.

Brain Res.

Brain Res.

Brain Res.

Lancet

Brain Res.

Neuroscience