Elsevier

Neuroscience Letters

Volume 131, Issue 1, 30 September 1991, Pages 66-70
Neuroscience Letters

Dopamine- and adenosine-3′:5′-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human☆

https://doi.org/10.1016/0304-3940(91)90338-TGet rights and content

Abstract

The cellular localization of a dopamine- and cAMP-regulated phosphoprotein of Mr 32,000 (DARPP-32) was investigated in cat, monkey and human retina by immunohistochemistry. In cat, DARPP-32-immunoreactive cell bodies identified as Müller cells were demonstrated in the inner nuclear layer (INL) with processes closely surrounding the cell some of photoreceptors in the outer nuclear layer. Some DARPP-32-IR cells were also seen in the nerve fiber layer (NFL) sending processes to the inner plexiform layer. In monkey and human retina, DARPP-32-IR cell bodies were also demonstrated in the INL, with few cells located in the NFL.

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    ☆

    This study was supported by grants from the Swedish MRC (04X-2887) and USPHS Grants MH40899 and MH43230, and Karin Sandqvist Stiftelse.

    1

    We thank Dr. E. Kock, Karolinska Hospital, Stockholm and Dr. A. Härfstrand and Ms. A.S. Holst, Pharmacia, Uppsala, Sweden for providing human and monkey tissue material, respectively.

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