Dopaminergic control of prolactin mRNA accumulation in the pituitary of the male rat

https://doi.org/10.1016/0303-7207(81)90099-XGet rights and content

Abstract

Dopaminergic control of the expression of the prolactin gene was investigated by administration of biomoergocryptine (CB154) to male rats. The effects of the drug on the following parameters were measured: (i) circulating levels of GH and PRL; (ii) synthesis of GH and PRL measured by pulse labeling pituitary fragments in vitro; (iii) GH and PRL mRNA activities; and (iv) content of PRL mRNA. After 1 day of CB154 administration, serum PRL fell to undetectable levels whereas it took 3 days to observe a 50% reduction in PRL synthesis. This effect was accounted for by a parallel decrease in PRL mRNA activity and content. GH synthesis and GH mRNA were not affected by the treatment. Our results show that the dopaminergic inhibition of PRL production involves regulation at a pre-translational level.

References (19)

  • P.S. Dannies et al.

    J. Biol. Chem.

    (1980)
  • R. Maurer

    J. Biol. Chem.

    (1980)
  • J.A.H. Wass et al.

    Lancet

    (1979)
  • T. Bergh et al.

    Acta Endocrinol. (Suppl.) (Copenhagen)

    (1978)
  • Brocas
  • G.A. Evans et al.
  • E. Flückiger
  • S.W.J. Lamberts et al.

    Endocrinology

    (1979)
  • M.P. Lutterbeck et al.

    Br. Med. J.

    (1971)
There are more references available in the full text version of this article.

Cited by (30)

View all citing articles on Scopus

Chercheur Qualifié au Fonds National de la Recherche Scientifique.

View full text