DNA structural variability as a factor in gene expression and evolution

doi:10.1016/0303-2647(86)90024-9

Biosystems

Volume 19, Issue 2, 1986, Pages 123-126

https://doi.org/10.1016/0303-2647(86)90024-9 Get rights and content

Abstract

Redundant DNA can buffer sequence dependent structural deviations from an ideal double helix. Buffering serves a mechanistic function by reducing extraneous conformational effects which could interfere with readout or which would impose energetic constraints on evolution. It also serves an evolutionary function by allowing for gradual variations in conformation-dependent regulation of gene expression. Such gradualism is critical for the rate of evolution. The buffer structure concept provides a new interpretation for repetitive DNA and for exons and introns.

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DNA structural variability as a factor in gene expression and evolution

Abstract

Bull. Math. Biol.

BioSystems

Int. J. Biol. Macromol.

FEBS Lett.

Restriction endonucleases can be used to study B-Z junctions in supercoiled DNA

Effects of methylation on a synthetic polynucleotide. The B-Z transition in Poly(dh.m5dc). Poly(dh.m5dc)

Adaptability

Selection for high mutation rates in chemostats

Genetics

Selfish genes, the phenotype paradigm and genome evolution

Nature

Effects of methylation on a synthetic polynucleotide. The B-Z transition in Poly(dh.m⁵dc). Poly(dh.m⁵dc)