APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum

doi:10.1016/0197-4580(89)90061-4

Neurobiology of Aging

Volume 10, Issue 3, May–June 1989, Pages 267-272

https://doi.org/10.1016/0197-4580(89)90061-4 Get rights and content

Abstract

We previously found a selective loss of the brain specific APP-695 transcript in Alzheimer's disease (AD) cortex, which results in a 2.5-fold increase in the APP-751/APP-695 transcript ratio in AD (9). Here we report a similar increase in APP-751/APP-695 mRNA ratio in AD hippocampus. However, the cerebellum had a 6-fold lower ratio, which does not change in AD. The APP-695 mRNA species is greatly decreased (3–4-fold) in mRNA from AD cortex and hippocampus, whereas the APP-751 mRNA species is essentially unchanged. Considering hippocampal neuron loss and cortical neuron loss and atrophy, the data presented may be compatible with increased APP-751 mRNA and decreased APP-695 mRNA prevalence in remaining neurons in AD. A possible relationship between a high APP-751/APP-695 ratio and amyloid pathology is discussed.

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Rapid communicationAPP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum

Abstract

Neurobiol. Aging

Neuroscience

Biochem. Biophys. Res. Commun.

Exp. Neurol.

Mech. Ageing. Dev.

Neuron.

Mol. Brain. Res.

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease

EMBO J.

Differential expression of mouse neural cell-adhesion molecule (N-CAM) mRNA species during brain development and in neural cell lines

J. Neurosci.

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and Alzheimer's disease