Research reportGlial-derived S100b protein selectively inhibits recombinant β protein kinase C (PKC) phosphorylation of neuron-specific protein F1/GAP43
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Cited by (59)
How serotonin receptors regulate morphogenic signalling in neurons
2017, Progress in NeurobiologyCitation Excerpt :The molecular mechanism behind the morphogenic actions of S-100β could involve the inhibition of PKC-induced phosphorylation of growth-associated protein 43 (GAP-43), microtubule-associated protein 2 (MAP-2), and tau − which would lead to increased polymerisation and stabilisation of microtubule assembly in target neurons. Moreover, S-100β can promote microtubule polymerisation by direct binding to tubulin (Baudier and Cole, 1988; Sheu et al., 1994; Whitaker-Azmitia et al., 1997). The signalling activity of 5-HT1 receptors is implicated in the pathogenesis of multiple behavioural and neurodegenerative disorders.
Cajal and brain plasticity: Insights relevant to emerging concepts of mind
2007, Brain Research ReviewsSerotonin and Brain: Evolution, Neuroplasticity, and Homeostasis
2007, International Review of NeurobiologyCitation Excerpt :The ability to promote neurite extension is attributed to its ability to prevent the phosphorylation of MAP proteins by PKC (Baudier and Cole, 1988; Sheu et al., 1994). This is an MAP‐specific inhibition since S100B does not inhibit PKC phosphorylation of histones (Sheu et al., 1994) and may be related to the ability of S100B to directly interact with MAPs (Donato et al., 1989). The route from the astrocytes where S100B is made to interact with the neuronal cytoskeleton may involve the receptor for advanced glycation endproducts (RAGE) (Hofmann et al., 1999; Rong et al., 2005).
Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: An immunohistochemical study of MAP-2, drebrin and GAP-43
2004, Brain ResearchCitation Excerpt :Finally, our results show an increase in GAP-43-ir in the aged S100B animals compared to the aged CD1 control mice, in the suprapyramidal blade of the dentate gyrus and CA1 stratum oriens. In vitro studies have shown that S100B inhibits phosphorylation of GAP-43 [27]. Phosphorylated GAP-43 is not active and thus axonal growth or plasticity would not take place [5].
S100B in schizophrenic psychosis
2004, International Review of Neurobiology
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Present address: National Institute of Child Health and Human Development, Endocrinology and Reproduction Research Branch, National Institutes of Health, Bldg 10, Rm B1L-400, Bethesda, MD 20892, USA.