The effects of substance P, histamine and histamine antagonists on somatostatin and gastrin release from the isolated perfused rat stomach
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Biological evaluation and molecular docking studies of AA3052, a compound containing a μ-selective opioid peptide agonist DALDA and D-Phe-Phe-D-Phe-Leu-Leu-NH<inf>2</inf>, a substance P analogue
2016, European Journal of Pharmaceutical SciencesCitation Excerpt :This, in consequence, might exclude the involvement of dopamine system in the observed effects. Similarly to this, several groups (Hermansen, 1980; McIntosh et al., 1987) indicated substance P to stimulate secretion of somatostatin (SOM), which apart from its antinociceptive effects (Chapman and Dickenson, 1992; Helyes et al., 2004; Pinter et al., 2006; Sandor et al., 2006) also induced barrel rotations (Van Wimersma Greidanus et al., 1987; Vécsei et al., 1989). This would fit well into our observations if not for the fact that SP inhibited the release and activity of SOM (McIntosh et al., 1987).
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