Conformational analysis of the antiinflammatory fenamates: a molecular mechanics and semiempirical molecular orbital study
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Polymorphism and conformations of mefenamic acid in supercritical carbon dioxide
2019, Journal of Supercritical FluidsCitation Excerpt :However, this was challenged by X-ray data. [41,42]. However, the exact path way involved in the formation of these polymorphic forms is still a subject of intensive researches [43–47]. In our work, we show that the conformational features of MA in CO2 phase and in its polymorphic forms are interdependent.
Thermal behavior, spectroscopic studies and free radical scavenging potential of some mefenamate trivalent lanthanides (Sm, Eu, Gd, Tb and Dy)
2017, Thermochimica ActaCitation Excerpt :Mefenamic acid is classified as a NSAID due to its antiproliferative and antioxidant properties. These properties were found to be enhanced when coordinated with certain bivalent transition metals, and this enhancement makes the development of new drugs possible [4,5,12]. Antioxidant action is important for the restoration of homeostasis and for treating diseases originating from free radicals [3,13,14].
The Crystal Structure and Behavior of Fenamic Acid-Acridine Complex Under High Pressure
2016, Journal of Pharmaceutical SciencesPreparation, characterization and evaluation of drug-delivery systems: Pectin and mefenamic acid films
2014, Thermochimica ActaCitation Excerpt :Mefenamic acid (2-[(2,3-dimethylphenyl)amino]benzoic acid) (H-Mef) is classified as a nonsteroidal anti-inflammatory drug (NSAID) which also displays antioxidant and antiproliferative activity in vitro against cells of three human cancer cell lines (human breast cancer cell line, bladder cancer cell line and non-small cell lung carcinoma) [4,11]. The therapeutic activity of NSAIDs is due to their ability to inhibit the biosynthesis of prostaglandins by competitive interaction with the cyclooxygenase-arachidonic acid complex in a reversible/irreversible manner (meclofenamic and indomethacin) or by radical quenching activity that interferes with the initiation of cyclooxygenase synthesis [4]. H-Mef has been found to exert neuroprotective effects and improve cognitive impairment in vitro and in vivo in Alzheimer’s disease models and also demonstrates neuroprotective activities against neurodegeneration [12].
Raman and IR spectroscopic studies of fenamates - Conformational differences in polymorphs of flufenamic acid, mefenamic acid and tolfenamic acid
2012, Spectrochimica Acta - Part A: Molecular and Biomolecular SpectroscopyCitation Excerpt :Inhibition of the COXs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs has been claimed to reduce the incidence of fatal thrombotic events, as well as the development of colon cancer [7] and Alzheimer’s disease [8]. Numerous individual analytical studies and quantitative methods have been documented, concerning various aspects of fenamates including important structural and physical properties [9–14]. Polymorphism is the ability of a compound, in the solid state, to exist in more than one crystalline form; such crystalline forms arise from a different arrangement of the molecules in a unit cell within a crystal lattice, and may involve conformational changes.
An experimental and theoretical vibrational spectroscopic study on niflumic acid, a non-steroidal anti-inflammatory drug
2010, Vibrational Spectroscopy