Trends in Pharmacological Sciences
Long term potentiation in the hippocampus: mechanisms of initiation and modulation by neurotransmitters
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Glutamate receptors and synaptic plasticity: The impact of Evans and Watkins
2022, NeuropharmacologyCitation Excerpt :Around this time, two seminal studies showed that the ability of Mg2+ to inhibit NMDARs was highly voltage-dependent (Nowak et al., 1984; Mayer et al., 1984) and due to a rapid block of the ion channel. We immediately realized that the voltage-dependence of the Mg2+ block has physiological relevance in the context of the induction of LTP (Collingridge, 1985). We proposed that during high-frequency transmission the temporal summation of AMPAR-mediated EPSPs provided the necessary depolarization to temporally relieve the Mg2+ block of NMDARs sufficiently to trigger LTP.
Foreword: The NMDA receptor 30 years on
2013, NeuropharmacologyThe NMDA receptor as a target for cognitive enhancement
2013, NeuropharmacologyCitation Excerpt :Some of the more important indirect modulators are described below and illustrated schematically in Fig. 1. During the induction of LTP, Hebbian depolarization is provided in part by the temporal summation of AMPAR-mediated EPSPs (Collingridge, 1985). Therefore one way, in theory, of boosting NMDAR function is to enhance the depolarization provided by the synaptic activation of AMPARs.
Emotional tagging-A simple hypothesis in a complex reality
2011, Progress in NeurobiologyCitation Excerpt :Although final, confirmatory experiments are still lacking, several experiments strongly suggest that there is indeed, a functional relationship between LTP-like synaptic strengthening and memory (Berger, 1984; Matthies et al., 1986; Rogan et al., 1997). In its classical form, LTP is induced by the activation of glutamate receptors of the NMDA type, which allows the entrance of calcium ions into the post-synaptic spine (Collingridge, 1985; Collingridge and Bliss, 1987). This NMDA-dependent LTP has been demonstrated in many brain areas, including the dentate gyrus (DG) and the CA1 hippocampal subfield, as well as in the amygdala (Bashir et al., 1991; Bashir and Collingridge, 1992; Rogan et al., 1997).
Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments
2007, Progress in Brain ResearchCitation Excerpt :This phenomenon, now referred to as long-term potentiation or LTP (Douglas and Goddard, 1975), required convergence of inputs onto granule cells or “cooperativity” (McNaughton et al., 1978), consistent with Hebb's neural postulate for association (Hebb, 1949). It was subsequently found that this electrophysiological demonstration of coincidence detection worked through a novel glutamatergic receptor, the NMDA receptor (Collingridge, 1985). The NMDA receptor was found to be voltage-dependent and to allow influx of calcium, presumed at that time to be necessary for initiating durable forms of plasticity.
The late maintenance of hippocampal LTP: Requirements, phases, 'synaptic tagging', 'late-associativity' and implications
2007, NeuropharmacologyCitation Excerpt :Therefore, the activation of NMDA receptors and CaM-dependent enzymes is necessary for the induction of both early- and late-LTP. However, since activation of NMDA-receptors alone results only in decremental LTP in CA1 neurons (Collingridge, 1985; Kauer et al., 1988), other glutamatergic or non-glutamatergic receptors and coupled second messengers must be involved at least for the induction of processes enabling the late-LTP. If the early-LTP (<4 h) is not dependent on newly synthesized proteins it might be based on modifications of pre-existing proteins, e.g. by phosphorylation by protein kinases.