Research paperThymomas express epitopes shared by the ryanodine receptor
References (25)
- et al.
Rabbit antiserum to a citric acid extract of human skeletal muscle staining thymomas from myasthenia gravis patients
J. Neuroimmunol.
(1984/85) - et al.
Antigen presentation by thymoma epithelial cells from myasthenia gravis patients to potentially pathogenic T cells
J. Neuroimmunol.
(1995) - et al.
Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum: comparative biochemical analysis of component activities
J. Biol. Chem.
(1979) - et al.
Two type of ryanodine receptors in mouse brain: skeletal muscle type exclusively in Purkinje cells and cardiac muscle type in various neurons
Neuron
(1992) - et al.
The ryanodine receptor/Ca2+ release channel
J. Biol. Chem.
(1993) - et al.
Myasthenia gravis patients with a thymoma have antibodies against a high molecular weight protein in sarcoplasmic reticulum
J. Neuroimmunol.
(1992) - et al.
Anti-skeletal muscle antibodies in the sera from myasthenic patients with thymoma: identification of anti-myosin, actomyosin, actin, and alpha-actinin antibodies by a solid-phase radioimmunoassay and a Western blotting analysis
Clin. Chim. Acta
(1990) - et al.
Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum
J. Biol. Chem.
(1990) Myasthenia gravis
Curr. Opin. Immunol.
(1993)- et al.
Patients with myasthenia gravis and thymoma have in their sera IgG autoantibodies against titin
Clin. Exp. Immunol.
(1990)
The pathology of the thymus gland in myasthenia gravis
Ann. N.Y. Acad. Sci.
Thymomatous epithelial cells and skeletal muscle share a common epitope defined by a monoclonal antibody
Am. J. Pathol.
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2019, The Autoimmune DiseasesThe Integrated Genomic Landscape of Thymic Epithelial Tumors
2018, Cancer CellCitation Excerpt :In non-thymic cancers, paraneoplastic autoimmune diseases typically emerge from immune processes directed to autoantigens that are common to the cancer and the target organ (Dalmau et al., 1992). By contrast, thymomas do not express bona fide complete AChR, titin, and RYR proteins (Marx et al., 1992; Mygland et al., 1995; Siara et al., 1991) but rather proteins with cross-reacting AChR, titin, and RYR epitopes (Marx et al., 1996; Mygland et al., 1995; Romi et al., 2002; Schultz et al., 1999). In this study, we confirm the TAMG-associated overexpression of the mid-size neurofilament gene, NEF, which harbors sequences coding for AChR and titin epitopes (Marx et al., 1996; Schultz et al., 1999).
Pathophysiology and immunological profile of myasthenia gravis and its subgroups
2017, Current Opinion in ImmunologyCitation Excerpt :Thymoma MG accounts for around 10–15% of all MG cases [6,7]. The immune response against an epitope expressed on thymoma cells spills over to neuromuscular junction components sharing the same epitope [8••,15]. In thymoma MG, epitopes are shared between the thymoma and muscle proteins.
Myasthenia Gravis and Related Disorders
2013, The Autoimmune Diseases: Fifth EditionMyasthenia Gravis and other Antibody-Associated Neurological Diseases
2006, The Autoimmune Diseases, Fourth Edition