Original articleAnalysis of chromosomal abnormalities in human sperm after chemotherapy by karyotyping and fluorescence in situ hybridization (FISH)☆
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2020, F and S ReportsCitation Excerpt :Despite having normal semen parameters, men treated with methotrexate had increased sperm oxidative stress and DNA fragmentation compared with control subjects (54). Case reports by Martin et al. and Melnyk et al., however, found that in their patients who used low-dose and high-dose methotrexate, respectively, chromosomal ploidy and structural abnormalities did not differ significantly compared with normal patients (55, 56). Pregnancy outcomes for couples conceiving naturally after paternal methotrexate therapy are more encouraging (Table 2).
Impact of Hodgkin or non-Hodgkin lymphoma and their treatments on sperm aneuploidy: a prospective study by the French CECOS network
2017, Fertility and SterilityCitation Excerpt :Several studies have investigated sperm aneuploidy following treatment of lymphoma. However, these studies included small series of lymphoma patients (from 1 to 12) and used different methods, such as sperm karyotyping (29, 31, 34) or FISH (30–33, 35, 36), whereas one study used single sperm array comparative genomic hybridization (46). Moreover, these were retrospective or case report studies, with the exception of one prospective study (35).
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2008, Reproductive ToxicologyGender effects on the incidence of aneuploidy in mammalian germ cells
2007, Environmental ResearchCisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation
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2004, Cancer Treatment Reviews
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This research was supported by the Medical Research Council of Canada, the Alberta Heritage Fund for Medical Research, and the Alberta Children's Hospital Research Foundation.
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The authors are grateful for the cooperation of the cancer patient who made this study possible. The expert technical assistance of Leona Barclay, Kathy Hildebrand, and Evelyn Ko, and the secretarial skills of Debbie Bell, are grately acknowledged.