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Induction of synaptic extracellular matrix molecules at ectopic neuromuscular junctions☆

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Abstract

The induction of synapse-specific molecules recognized by peanut agglutinin (PNA) was examined at ectopic neuromuscular junctions in adult frog muscles using light and electron microscopy. In normal frog muscles, PNA specifically recognizes the extracellular matrix at neuromuscular junctions but not at extrajunctional regions. This report shows binding of PNA at ectopic neuromuscular junctions which were initially extrasynaptic and hence unrecognized by PNA. Results suggest that synapse-specific extracellular matrix molecules can be induced de novo at new junctional sites.

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    • ☆

    This work was supported by NIH Grant NS 17954 and a Muscular Dystrophy Association Research Grant and completed with the technical assistance of Mary Mosbacher and Carol Osaka.

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    Copyright © 1990 Published by Elsevier B.V.