Research reportPostnatal development of multiple opioid receptors in rat brain
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Cited by (39)
Age-dependent effects of Κ-opioid receptor stimulation on cocaine-induced stereotyped behaviors and dopamine overflow in the caudate-putamen: An in vivo microdialysis study
2010, NeuroscienceCitation Excerpt :When the results of the present experiments are considered together, it appears that κ-opioid receptors in the CPu do not modulate dopaminergic functioning in a similar fashion during the preweanling period and in adulthood. The inability of U50,488 to block cocaine-induced dopamine overflow was not due to the late development of U50,488 binding sites, because κ-opioid receptor densities and mRNA levels are at approximately adult-like levels by PD 17 (Kornblum et al., 1987; Leslie and Loughlin, 1993; Georges et al., 1998). In adulthood, κ-opioid receptor stimulation activates voltage-dependent K+ channels and inhibits both adenylyl cyclase activity and voltage-dependent Ca2+ channels via inhibitory Gi and Go proteins (for reviews, see Childers, 1991; Minami and Satoh, 1995; Connor and Christie, 1999).
Developmental expression of μ and δ opioid receptors in the rat brainstem: Evidence for a postnatal switch in μ isoform expression
2004, Developmental Brain ResearchConsolidation and expression of a shock-induced odor preference in rat pups is facilitated by opioids
2003, Physiology and BehaviorDevelopmental changes of <sup>3</sup>H-labelled μ-opioid receptors in brainstems of intra-uterine growth-restricted rats
2001, Developmental Brain ResearchThe role of opioid receptors in morphine withdrawal in the infant rat
2000, Developmental Brain Research
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