Elsevier

Immunology Letters

Volume 1, Issue 2, October 1979, Pages 85-91
Immunology Letters

Independence of anti-allotype antibody titers and “allotype interference” properties of anti-allotype antisera of rabbits

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Abstract

Allotypic interference, i.e. the capacity of anti-allotype antisera to inhibit antigen binding, is not correlated with the anti-allotype antibody titer of antisera. This rules out the possibility that all anti-allotype antibodies are endowed with interfering activity.

It is suggested that this activity may be possessed by a minor subpopulation of anti-allotype-associated antibodies, possibly by those directed against variable region determinant(s).

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