Cell
Volume 78, Issue 4, 26 August 1994, Pages 543-546
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How loops, β sheets, and α helices help us to understand p53

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      Ectopic expression of wild-type p53 inhibited hormonally induced adipocyte differentiation of wild-type MEFs as determined by triglyceride staining with Oil Red O (Fig. 1A) and adipocyte marker gene expression (Fig. 1B). The inhibitory effect was dependent on the ability of p53 to bind to DNA, as a p53 mutant with impaired DNA binding ability (p53 R175D) (25) failed to inhibit adipose conversion of wild-type MEFs (Fig. 1A, B). Although p53 and p53 R175D were both expressed (supplementary Fig. IIA), only wild-type p53 induced expression of p21 (supplementary Fig. IIB) confirming the transcriptional inactivity of the p53 R175D mutant.

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