Cell
MinireviewHow loops, β sheets, and α helices help us to understand p53
References (27)
- et al.
Cell
(1992) - et al.
Cell
(1991) - et al.
Genes Dev.
(1991) - et al.
Genes Dev.
(1993) - et al.
Science
(1994) - et al.
Nature
(1993) - et al.
Science
(1994) - et al.
- et al.
EMBO J.
(1993) Nucl. Acids Res.
(1994)
Nucl. Acids Res.
Oncogene
Cited by (169)
PPARγ ligand production is tightly linked to clonal expansion during initiation of adipocyte differentiation
2014, Journal of Lipid ResearchCitation Excerpt :Ectopic expression of wild-type p53 inhibited hormonally induced adipocyte differentiation of wild-type MEFs as determined by triglyceride staining with Oil Red O (Fig. 1A) and adipocyte marker gene expression (Fig. 1B). The inhibitory effect was dependent on the ability of p53 to bind to DNA, as a p53 mutant with impaired DNA binding ability (p53 R175D) (25) failed to inhibit adipose conversion of wild-type MEFs (Fig. 1A, B). Although p53 and p53 R175D were both expressed (supplementary Fig. IIA), only wild-type p53 induced expression of p21 (supplementary Fig. IIB) confirming the transcriptional inactivity of the p53 R175D mutant.
A cationic cholesterol based nanocarrier for the delivery of p53-EGFP-C3 plasmid to cancer cells
2014, BiomaterialsCitation Excerpt :The p53 gene encodes a nuclear transcription factor which is mutated or lost in a majority of human cancers [3,4]. Crystal structure reveals the presence of mutations in the DNA-binding domain of the protein [5], which abolishes its ability to trans-activate its target genes [6]. A p53-mediated apoptosis in response to DNA damage is achieved by the stabilization of the existing wt p53 protein.
Spectrometric studies on interaction between metal ions and DNA-binding domain of tumor suppressor protein p53
2009, Fenxi Huaxue/ Chinese Journal of Analytical ChemistryCrystal structure of a superstable mutant of human p53 core domain: Insights into the mechanism of rescuing oncogenic mutations
2004, Journal of Biological Chemistry(1-Benzimidazolonyl)alanine (Bia): Preliminary investigations into a potential tryptophan mimetic
2002, Tetrahedron Letters