Coding of olfactory information: Topography of odorant receptor expression in the catfish olfactory epithelium

doi:10.1016/0092-8674(93)90396-8

Cell

Volume 72, Issue 5, 12 March 1993, Pages 667-680

https://doi.org/10.1016/0092-8674(93)90396-8 Get rights and content

Abstract

Discrimination among the vast array of odors requires that the brain discern which of the numerous odorant receptors have been activated. If individual olfactory neurons express only a subset of the odorant receptor repertoire, then the nature of a given odorant can be discerned by identifying which cells have been activated. We performed in situ hybridization experiments demonstrating that individual olfactory neurons express different complements of odorant receptors and are therefore functionally distinct. Thus, a topographic map, defining either the positions of specific neurons in the epithelium or the positions of their projections, may be employed to determine the quality of an olfactory stimulus. Neurons expressing specific receptors appear to be randomly distributed within the olfactory epithelium. These data are consistent with a model in which randomly dispersed olfactory neurons with common receptor specificities project to common glomeruli in the olfactory bulb.

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^†: Present address: Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720.

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Cell

ArticleCoding of olfactory information: Topography of odorant receptor expression in the catfish olfactory epithelium

Abstract

Comp. Med. Imag. Graph.,

Brain Res. Bull.,

Dev. Brain Res.,

Brain Res.,

Cell

Tiss. Cell

Tiss. Cell

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Neuron

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Prog. Neurobiol.,

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Brain Res.,

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J. Steroid Biochem. Mol. Biol.,

Prog. Neurobiol.,

Brain Res.,

Neuron

Brain Res.,

Prog. Neurobiol.,

Brain Res.,

Brain Res.,

Physiol. Behav.,

Brain Res.,

Cell

Sensory discrimination: with some recent evidence from the olfactory organ

Brit. Med. Bull.,

Piriform cortex and olfactory object recognition

Electrophysiological evidence for a topographical projection of the nasal mucosa onto the olfactory bulb of the frog

J. Gen. Physiol.,

Article
Coding of olfactory information: Topography of odorant receptor expression in the catfish olfactory epithelium