Cell
ArticleThe dynamics of protein phosphorylation in bacterial chemotaxis
References (45)
- et al.
Transmembrane signaling by bacterial chemoreceptors: E. coli transducers with locked signal output
Cell
(1988) - et al.
Protein phosphorylation in chemotaxis and two-component regulatory systems of bacteria
J. Biol. Chem.
(1989) - et al.
G protein involvement in receptor-effector coupling
J. Biol. Chem.
(1988) - et al.
Phosphorylation of three proteins in the signaling pathway of bacterial chemotaxis
Cell
(1988) - et al.
Phosphorylation of an N-terminal regulatory domain activates the CheB methylesterase in bacterial chemotaxis
J. Biol. Chem.
(1989) - et al.
Mutants defective in bacterial chemotaxis show modified protein phosphorylation
Cell
(1988) Signal sorting and amplification through G protein-coupled receptors
Neuron
(1989)- et al.
Identification of the site of phosphorylation of the chemotaxis response regulator protein, CheY
J. Biol. Chem.
(1989) - et al.
Regulation of transmembrane signaling by receptor phosphorylation
Cell
(1987) - et al.
Identification of a possible nucleotide binding site in CheW, a protein required for sensory transduction in bacterial chemotaxis
J. Biol. Chem.
(1987)
Sensory transduction in bacterial chemotaxis involves phosphotransfer between Che proteins
Biochem. Biophys. Res. Commun.
“Decision”-making in bacteria: chemotactic response of Escherichia coli to conflicting stimuli
Science
Transient response to chemotactic stimuli in Escherichia coli
Transmembrane signal transduction in bacterial chemotaxis involves ligand-dependent activation of phosphate group transfer
Conserved aspartate residues and phosphorylation in signal transduction by the chemotaxis protein CheY
G proteins: transducers of receptor-generated signals
Annu. Rev. Biochem.
Sensory transduction in Escherichia coli: role of a protein methylation reaction in sensory adaptation
Protein phosphorylation is involved in bacterial chemotaxis
Protein phosphorylation and bacterial chemotaxis
Histiuine phosphorylation and phosphoryl group transfer in bacterial chemotaxis
Nature
Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NtrB and NtrC of enteric bacteria: roles of conserved amino-terminal domain of NtrC
Chemotaxis as a model second-messenger system
Biochemistry
Cited by (151)
Recent structural advances in bacterial chemotaxis signalling
2023, Current Opinion in Structural BiologyRegulation of the chemotaxis histidine kinase CheA: A structural perspective
2020, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Early work demonstrated that Ec CheA operates at three general levels of autophosphorylation: a “closed” state in its free form, an “open” or “on” state when complexed with chemoreceptors and a “sequestered” or “off” state when the receptors were bound to chemoattractants [129,130]. The receptor-inhibited or off state was designated as “sequestered” because, unlike the open state, the sequestered state cannot exchange phosphate with ATP or ADP [129]. Moreover, although sequestered CheA can be dephosphorylated by CheY, further autophosphorylation is blocked [129].
Conformational Transitions that Enable Histidine Kinase Autophosphorylation and Receptor Array Integration
2015, Journal of Molecular BiologyCheA-receptor interaction sites in bacterial chemotaxis
2012, Journal of Molecular BiologyCitation Excerpt :CheA utilizes ATP that binds to the P4 domain to phosphorylate a histidine residue in the P1 domain. This trans-autophosphorylation is modulated by the interaction network among chemoreceptors, CheW, and the P5 domain of CheA.5–9 CheW serves as an adaptor that is essential for the formation of receptor–CheW–CheA complex and CheA activation.7
Structural insight into the low affinity between Thermotoga maritima CheA and CheB compared to their Escherichia coli/Salmonella typhimurium counterparts
2011, International Journal of Biological MacromoleculesCitation Excerpt :However, the CW rotation forces the flagella bundle to fall apart and results in a tumbling motion necessary to randomly change the swimming orientation. The relative amount of time spent in the CCW vs. CW rotation (i.e., smooth-swim vs. tumble) determines the overall bacterial locomotion against the existing chemical stimuli [1–10]. Chemotaxis signaling begins in response to change in chemoreceptor's ligand occupancy, which affects the auto-kinase CheA activity to phosphorylate a histidine residue on its phosphotransfer domain.