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Centriole deciliation associated with the early response of 3T3 cells to growth factors but not to SV40
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Tubastatin A maintains adult skeletal muscle stem cells in a quiescent state ex vivo and improves their engraftment ability in vivo
2022, Stem Cell ReportsCitation Excerpt :One of the most important developmental pathways regulated by this organelle is the Hedgehog (Hh) signaling pathway (Anvarian et al., 2019; Huangfu et al., 2003). Primary cilia assembly and disassembly are intimately linked to cell cycle progression, with the primary cilia beginning to disassemble as cells enter the cell cycle (Kim and Tsiokas, 2011; Quarmby and Parker, 2005; Tucker et al., 1979b). The histone deacetylase 6 (Hdac6) plays a crucial role in promoting ciliary resorption by inducing the deacetylation of axonemal microtubules (de Diego et al., 2014; Pugacheva et al., 2007).
Primary ciliary signaling: links with the cell cycle
2021, Trends in Cell BiologyCitation Excerpt :The primary cilium is an antenna-like organelle built upon a membrane-anchored basal body (see Glossary) [1–3]. The cell cycle dependence of ciliary assembly and disassembly was first suggested almost 50 years ago [4–6]. Ciliary assembly is generally observed in G1 or following cell cycle exit in the G0 phase in response to serum starvation, whereas ciliary disassembly is either accompanied or triggered by cell cycle re-entry upon restimulation with serum.
A novel role of KIF3b in the seminoma cell cycle
2017, Experimental Cell ResearchCitation Excerpt :KIF3b is also distributed in the cell cortex near the cell membrane (Fig. 4). As has showed in previous reports, kinesin-2 mediated IFT is involved in primary cilia formation [32–35]. Therefore, the silencing of KIF3b will surely have an impact on ciliogenesis.
The cilium–centrosome axis in coupling cell cycle exit and cell fate
2023, Journal of Cell Science