Cell
ArticleX and Y chromosomal ribosomal DNA of drosophila: comparison of spacers and insertions
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Under the magnifying glass: The ups and downs of rDNA copy number
2023, Seminars in Cell and Developmental BiologyCitation Excerpt :As Oscar Miller first noted, inserted rDNA cistrons are poorly expressed ([38], also see [50,123]). What keeps inserted cistrons at this low level of expression is not fully elucidated, but most-likely includes a combination of sequence-specific [119,26] and regional factors such as proximity or “epigenetic” memory [17,51,53]. Silencing R1- and R2-inserted cistrons is desirable because if expressed, they are expected to alter the strict stoichiometry that naturally arises from the co-expression of the 18 S, 5.8 S, and 28 S portions of the 35 S primary rRNA transcript [51].
A New Portrait of Constitutive Heterochromatin: Lessons from Drosophila melanogaster
2019, Trends in GeneticsCitation Excerpt :The X and Y clusters consist of about 2.2 and 2.8 Mb, respectively, mapping to mitotic regions h29 and h20 (Figure 1, Table 2, and Tables S1 and S2 in the supplemental information online). The basic rDNA unit is 11.5 kb, but can differ in the intergenic spacer length (IGS), the internal transcribed spacer, and the distribution of R1 and R2 elements [59–61]. The rDNA copy number ranges from 80 to 600 [61–64], where individuals with <130 copies display the bobbed mutant phenotype [65].
Genetic Organization of Polytene Chromosomes
1999, Advances in GeneticsPolytene Chromosomes, Heterochromatin, and Position Effect Variegation
1997, Advances in Genetics