ArticleEffects of Ventral Tegmental Microinjections of the GABAA Agonist Muscimol on Self-Administration of Ethanol and Sucrose
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Interactions of Alcohol and Nicotine: CNS Sites and Contributions to Their Co-abuse
2017, Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday LifestylesSite-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice
2014, Behavioural Brain ResearchCitation Excerpt :Previous work evaluating the role of mesolimbocortical GABAA receptors in rodent ethanol consumption has offered valuable insight on region-specific GABAA receptor signaling. Infusion of the GABAA agonist, muscimol, into the VTA was observed to have no effect on operant responding for ethanol in rats [48], although infusion into the mPFC reduced ethanol intake [49]. Other studies demonstrated that GABAA antagonism in both the anterior region of the VTA [50] and extended amygdala [51] reduced ethanol intake.
Involvement of tissue plasminogen activator "tPA" in ethanol-induced locomotor sensitization and conditioned-place preference
2012, Behavioural Brain ResearchCitation Excerpt :It is well established that alcohol intake increases the release of dopamine and subsequently increases gene expression in mesencephalic brain areas related to reinforcement and reward, such as the nucleus accumbens (NAc) or the ventral part of striatum [2–6]. In these regions, alcohol-induced opioid release stimulates dopamine neurons by acting directly on the NAc and by disinhibiting GABA neurons projecting into the ventral tegmental area (VTA) [7–13]. Several recent reports have suggested a close interaction between the plasminogen system and drug of abuse.
Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats
2010, AlcoholCitation Excerpt :There is evidence that the mesolimbic DA system is involved in regulating alcohol drinking (reviewed in Koob et al., 1998). Several microinjection studies indicated that the VTA is involved in regulating alcohol drinking (Hodge et al., 1993a, 1996; Katner et al., 1997; Nowak et al., 1998, 2000). Moreover, the studies of Hodge et al. (1993a) and Nowak et al. (2000) indicated that microinfusion of quinpirole, a DA D2 receptor agonist, reduced ethanol intake, suggesting that activation of VTA DA neurons is involved in maintaining ethanol drinking.
Strain Specific Synaptic Modifications on Ventral Tegmental Area Dopamine Neurons After Ethanol Exposure
2009, Biological PsychiatryCitation Excerpt :Alcoholism research attempts to identify the neural adaptations associated with the disease, whereby highlighting potential therapeutic targets. Because alcoholism involves both genetic and environmental components (1,2), it is often difficult to determine the critical neural regions associated with alcoholism, especially because the primary effects of ethanol are widespread throughout the central nervous system (15,16), although a number of studies have identified a role for the VTA and dopamine in ethanol-related behaviors (3,17–19,21–23,64). Many lines of evidence suggest that lower function of the dopamine system is associated with increased alcohol consumption in both rodents and humans (6,7,27,30,34), perhaps reflecting the drive to overcome a low dopamine state during early withdrawal (15).
Ethanol intake patterns in female mice: Influence of allopregnanolone and the inhibition of its synthesis
2008, Drug and Alcohol Dependence
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