Effects of heroin and naloxone on cerebral blood flow in the conscious rat
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Interaction of adenosine and naloxone on regional cerebral blood flow in morphine-dependent rats
2006, Brain ResearchCitation Excerpt :Opioid receptor binding has been demonstrated on cerebral micro vessels (Peroutka et al., 1980). Heterogeneous increase in regional cerebral blood flow (rCBF) 3 min after a single, acute dose of heroin or naloxone has been reported in the conscious rat (Fuller and Stein, 1991). It has been reported that morphine administration reduced rCBF in the control group and morphine-dependent rats (MDR), but the depressant effect of morphine in dependent rats was less than that in the control group.
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