Evidence that shock-induced immune suppression is mediated by adrenal hormones and peripheral β-adrenergic receptors

doi:10.1016/0091-3057(90)90270-R

Pharmacology Biochemistry and Behavior

Volume 36, Issue 3, July 1990, Pages 645-651

https://doi.org/10.1016/0091-3057(90)90270-R Get rights and content

Abstract

Our previous work has demonstrated that presentations of mild foot-shock to Lewis rats induces a suppression of splenic and peripheral blood lymphocyte responses to nonspecific T-cell mitogens. The present study demonstrated that adrenalectomy prevented the shock-induced suppression of the mitogenic response of peripheral blood T-cells but did not attenuate the suppression of splenic T-cells. Conversely, the beta-adrenergic receptor antagonists, propranolol and nadolol, attenuated the shock-induced suppression of splenic T-cells in a dose-dependent manner but did not attenuate suppression of the blood mitogen response. These data indicate that distinct mechanisms mediate the shock-induced suppression of T-cell responsiveness to mitogens in the spleen and the peripheral blood. The results indicate that the peripheral release of catecholamines is responsible for splenic immune suppression and that adrenal hormones, which do not interact with β-adrenergic receptors, are responsible for shock-induced suppression of blood mitogenic responses.

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Evidence that shock-induced immune suppression is mediated by adrenal hormones and peripheral β-adrenergic receptors

Abstract

Lancet

Life Sci.

Exp. Cell Res.

Brain Behav. Immun.

Cell. Immunol.

Int. J. Immunopharmacol.

Life Sci.

Brain Behav. Immun.

Life Sci.

Brain Behav. Immun.

Life Sci.

J. Biol. Chem.

Pharmacology of nadolol

Modulation of inflammation and immunity by cyclic AMP

Science