Metoclopramide potentiates d-amphetamine-induced hypermotility and stereotypy in rat

doi:10.1016/0091-3057(87)90491-6

Pharmacology Biochemistry and Behavior

Volume 27, Issue 1, May 1987, Pages 165-169

https://doi.org/10.1016/0091-3057(87)90491-6 Get rights and content

Abstract

The substituted benzamide metoclopramide has been reported to block the behavioral effects of dopamine agonists, whereas its congener sulpiride potentiates these effects. We injected metoclopramide 2.0, 4.0, or 8.0 mg/kg PO into rats 2 hr before d-amphetamine 1.5 mg/kg IP and measured locomotion for 3 hr. We injected metoclopramide 8.0 mg/kg PO into rats 2 hr before d-amphetamine 1.5, 3.0, or 6.0 mg/kg IP and measured stereotypy for 3 hr. Metoclopramide potentiated the effects of all doses of d-amphetamine on both measures; peak effects occurred in the second or third hr after d-amphetamine injection. Metoclopramide alone tended to reduce behavior. The results suggest that metoclopramide is qualitatively similar to sulpiride in its interaction with d-amphetamine, and that metoclopramide's mechanism of action is not a simple dopaminergic antagonism. Clinicians are advised that metoclopramide, which is prescribed extensively for gastrointestinal and other disorders, may interact adversely with drugs that affect dopaminergic function.

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¹: Present address: Pharmaceuticals Division, Biomedical Products Department, E. I. duPont de Nemours & Co., Experimental Station, Wilmington, DE 19810.

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Metoclopramide potentiates d-amphetamine-induced hypermotility and stereotypy in rat

Abstract

Eur J Pharmacol

Eur J Pharmacol

Eur J Pharmacol

Pharmacol Biochem Behav

Eur J Pharmacol

Eur J Pharmacol

Pharmacol Biochem Behav

Eur J Pharmacol

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