Concurrent heroin self-administration and intracranial self-stimulation in rats
References (18)
- et al.
Opioids and rewarding brain stimulation
Neurosci Biobehav'Rev
(1978) - et al.
Small dose intravenous heroin facilitateshypothalamic self-stimulation without response suppression in rats
Life Sci
(1981) - et al.
Temporal analysis of naloxone attenuation of morphine-induced taste aversion
Pharmacol Biochem Behav
(1977) - et al.
Concurrent intracranial self-stimulation and intravenous amphetamine self-administration in rats
Pharmacol Biochem Behav
(1977) - et al.
Brain reward circuity: Four circuit elements ”wired“ in apparent series
Brain Res Bull
(1984) Opiate reward mechanisms mapped by intracranial self-administration
- et al.
Separation of inhibiting and stimulating effects of morphine on self-stimulation behavior by intracerebral microinjections
Eur J Pharmacol
(1976) - et al.
Addictive agents and intracranial stimulation: Daily morphine and lateral hypothalamic self-stimulation
Physiol Psychol
(1976) Quantitative variation of incentive and performance in the white rats
Am J Psychol
(1940)
Cited by (12)
Pharmacotherapies for decreasing maladaptive choice in drug addiction: Targeting the behavior and the drug
2018, Pharmacology Biochemistry and BehaviorCitation Excerpt :Sullivan et al. (2006) found that naltrexone, when administered chronically as a depot implant, reduced heroin choice in humans. Similar findings have been reported with the shorter-acting opioid antagonist, naloxone, in rats (Gerber et al., 1985), NHPs (Negus, 2006), and humans (when combined with buprenorphine; Comer et al., 2005). It should be noted, however, that for opioid abusers, the effects of mu-opioid antagonists can vary widely depending on the current state of the patient on a dependence continuum.
Insights from Preclinical Choice Models on Treating Drug Addiction
2017, Trends in Pharmacological SciencesCitation Excerpt :To date, preclinical drug versus nondrug choice procedures have been established for the abused drugs cocaine [20–22], methamphetamine [23,24], 3,4-methylenedioxymethamphetamine [25], heroin [26,27], remifentanil [28], secobarbital and chlordiazepoxide [29], and nicotine [30] in either nonhuman primates or rats. With the exception of one heroin versus electrical brain stimulation choice study [31], all other preclinical drug versus nondrug choice procedures have used some food variant as the alternative nondrug reinforcer. This body of literature has suggested three main findings.
The predictive validity of the rat self-administration model for abuse liability
2011, Neuroscience and Biobehavioral ReviewsProgressive ratio schedules in drug self-administration studies in rats: A method to evaluate reinforcing efficacy
1996, Journal of Neuroscience MethodsMedications development for treatment of opioid use disorder
2021, Cold Spring Harbor Perspectives in MedicineMedications development for opioid abuse
2013, Cold Spring Harbor Perspectives in Medicine