Elsevier

Virology

Volume 168, Issue 1, January 1989, Pages 162-167
Virology

Short communication
Monoclonal antibodies to the matrix (El) glycoprotein of mouse hepatitis virus protect mice from encephalitis

https://doi.org/10.1016/0042-6822(89)90415-7Get rights and content

Abstract

Monoclonal antibodies to the matrix or El glycoprotein of mouse hepatitis virus (MHV) were tested for their ability to protect mice from a normally lethal challenge of MHV-4. Four antibodies were tested, and two of these,J.1.3 and J.3.9, were protective. Protection did not correlate with virus neutralization in vitro, antibody isotype, recognition of a unique El antigenic site, or dependence on complement in vivo. Survival from acute encephalitis was followed by subacute demyelination, as has been shown with protection mediated by neutralizing monoclonal antibodies against the major glycoprotein, E2. These results demonstrate that antibodies which are specific for a viral matrix protein are able to alter the course of disease.

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Present address: Department of Microbiology, Chicago College of Osteopathic Medicine, Chicago, IL 60615.

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