Elsevier

Virology

Volume 136, Issue 1, 15 July 1984, Pages 247-252
Virology

Short communication
Enhancement of viral hepatitis B antibody (anti-HBs) response to a synthetic cyclic peptide by priming with anti-idiotype antibodies

https://doi.org/10.1016/0042-6822(84)90264-2Get rights and content

Abstract

In vivo injections of anti-idiotype antibodies were used to prime the immune system of mice to hepatitis B surface antigen (HBsAg). Anti-idiotype reagents in conjunction with a cyclic synthetic peptide analogous to positions 122–137 of HBsAg induced an antibody response to HBsAg (anti-HBs) comparable to that obtained with a single injection of intact HBsAg particles. In addition, high anti-HBs titers were produced in mice injected with HBsAg following anti-idiotype priming. These data indicate that anti-idiotype antibodies may be useful in priming the immune system of a host to a potential infectious agent.

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