Elsevier

Virology

Volume 83, Issue 1, November 1977, Pages 27-33
Virology

The distribution of virus-specific RNA in Rous sarcoma virus-induced hamster tumor cells

https://doi.org/10.1016/0042-6822(77)90208-2Get rights and content

Abstract

Poly(A)-containing cytoplasmic RNA and nuclear RNA from Rous sarcoma virus (RSV)-induced hamster tumor cells was fractionated on sucrose density gradients and hybridized with a [3H]cDNA probe to determine the size distribution of virus-specific RNA. One size class of viral RNA sedimenting at 21 S was detected in cytoplasmic poly(A)-containing RNA. Nuclear RNA contained three species of virus-specific RNA sedimenting at 47, 35, and 21 S. Sedimentation of nuclear RNA under denaturing conditions did not change this size distribution.

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